Circulating Tumour Dna as a Personalised Biomarker in Breast Cancer

Characterizing the cancer genome in blood

SJ Dawson

2019-04-01

Cell-free circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) can be found in the bloodstream of individuals with can..

The value of cell-free DNA for molecular pathology

CM Stewart, PD Kothari, F Mouliere, R Mair, S Somnay, R Benayed, A Zehir, B Weigelt, SJ Dawson, ME Arcila, MF Berger, DWY Tsui

2018-04-01

Over the past decade, advances in molecular biology and genomics techniques have revolutionized the diagnosis and treatment of can..

Circulating tumor DNA guides prognosis in metastatic triple-negative breast cancer

AZ Bujak, SJ Dawson

2018-02-20

Wet or dry? Do liquid biopsy techniques compete with or complement pet for disease monitoring in oncology?

SQ Wong, RW Tothill, SJ Dawson, RJ Hicks

2017-06-01

Reversion of BRCA1/2 germline mutations detected in circulating tumor DNA from patients with high-grade serous ovarian cancer

EL Christie, S Fereday, K Doig, S Pattnaik, SJ Dawson, DDL Bowtell

2017-04-20

Purpose Germline BRCA1 or BRCA2 mutations in patients with high-grade serous ovarian cancer (HGSC) are associated with favorable r..

Molecular disease monitoring using circulating tumor DNA in myelodysplastic syndromes

P Yeh, M Dickinson, S Ftouni, T Hunter, D Sinha, SQ Wong, R Agarwal, R Vedururu, K Doig, CY Fong, P Blombery, D Westerman, MA Dawson, SJ Dawson

2017-03-23

The diagnosis andmonitoring of myelodysplastic syndromes (MDSs) are highly relianton bone marrow morphology, which is associated w..

Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

P Yeh, T Hunter, D Sinha, S Ftouni, E Wallach, D Jiang, YC Chan, SQ Wong, MJ Silva, R Vedururu, K Doig, E Lam, GM Arnau, T Semple, M Wall, A Zivanovic, R Agarwal, P Petrone, K Jones, D Westerman

2017-03-17

Several novel therapeutics are poised to change the natural history of chronic lymphocytic leukaemia (CLL) and the increasing use ..

The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program “CASCADE”

P Savas, ZL Teo, C Lefevre, C Flensburg, F Caramia, K Alsop, M Mansour, PA Francis, HA Thorne, MJ Silva, N Kanu, M Dietzen, A Rowan, M Kschischo, S Fox, DD Bowtell, SJ Dawson, TP Speed, C Swanton, S Loi

2016-12-01

Background: Understanding the cancer genome is seen as a key step in improving outcomes for cancer patients. Genomic assays are em..

Blood worth bottling: Circulating tumor DNA as a cancer biomarker

EL Christie, SJ Dawson, DDL Bowtell

2016-10-01

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

B Pereira, SF Chin, OM Rueda, HKM Vollan, E Provenzano, HA Bardwell, M Pugh, L Jones, R Russell, SJ Sammut, DWY Tsui, B Liu, SJ Dawson, J Abraham, H Northen, JF Peden, A Mukherjee, G Turashvili, AR Green, S McKinney

2016-05-10

The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating ..

Circulating tumor cells and circulating tumor DNA for precision medicine: Dream or reality?

M Ignatiadis, SJ Dawson

2014-12-01

Next-generation sequencing studies have provided further evidence to support the notion that cancer is a disease characterized by ..